I'd love to see a 300 2T up with the 450Fs, but its not gonna happen with any useful regularity.
Apart from modern 450Fs being faster and easier to ride across the average of all possible conditions, the manufacturers are paying the best riders to ride 4-strokes - so the top tier riders are already on 4Ts. The only time you'll see a 2T up there is if you had a talented up-and-comer on a properly sorted bike, and the conditions were just right - it would be awesome to see, but its not going to be a long term, sustainable thing.