Lozza, thanks for your informative reply, if I wanted to play games I would have asked my kids rather than bothering all the helpful and friendly like minded people on the forum.
Here's my thoughts anyway on what may happen.
Apart from loosing the lube effect at the bridge which is an important issue on it's own, you'd also probably loose some, or more of your fuel mix straight out the exhaust rather than being transferred up into the chamber resulting in lack of potential performance. I was thinking it may also cause a loss of compression, but on second thoughts I think not, transfer would be the main issue.
My main reason for posting the question was to ask without any prompts of possible answers and to get a second, third, fourth... opinions and whether I should just lash out and get a new wiseco and drill the holes myself in the right position. Unfortunately the piston I have now has the holes already pre-drillled.