BretB81,
Something is not right. I have a PE250N that has just has a complete rebuild 1.00mm over. It is fitted with a RM expansion chamber and an aftermerket muffler. I am running the standard pilot, 2.0 slide, the needle in the centre position and a 290 main jet. Cant remember what the Needle Jet or the needle is but i would be taking a guess that it is stsnadard. With the air screw out 1.5 turns, the combination starts hot and cold with no issue, idles fine and pulls like a train through the whole rev range. Motocross or single track riding and every thing is fine. Do you have any idea as to the condition of the cranks seals or centre case gasket? What plug are you running?