I know of someone who (in the 1980s) welded up the reed intake holes in DT175 pistons to use them in Lambretta piston-ported racing engines, so it can work. However, if it is only exhaust-bridge-lubricating holes you are dealing with, I wouldn't bother. I have been running a PE250 piston in a non-PE cylinder (with a single unbridged exhaust port) for more than 10,000km and the lubricating holes don't seem to cause any trouble.
Regards,
James