The further up the slippery slope of tuning you go,the better the plug that is required. A 125 kart engine tuned to the point of detonation each time it hit the track, would not complete a lap on a EV,EGV or EG plug demanded an iridium plug. When we switched to proper race plugs laptimes dropped and took a tooth off the rear.
PULP is great fuel, consitenetly consistent, doesn't care what engine it's in you just have to learn what to do to get the most out of it.
Led to believe methanol likes ES plugs but have heard of people using EG/EGV/EV plugs.