RM1976,
Your're still way to lean on the main for a RM125S. If you're running out of legs at the top, the bigger main should help, or like said earlier, you may end up witha hole in the top of the piston. Are you sure you have an S, they have a 34mm carby.
Standard carby spec's for a S is:
Main #280
Pilot #35
Needle #6DH3 (third clip from top)
Needle jet P-3
Air screw: 1 turn out